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OZONE THERAPY
What is Ozone Therapy?
Ozone is a highly-charged molecule with oxygenating properties. When taken into the body, it delivers higher levels of oxygen to tissue, improving its ability to regenerate, boosting the immune system’s ability to fight infection, and increasing overall metabolism. Ozone therapy has been commonly used in Germany since the 1950s. Doctors and medical practitioners use it to treat a variety of degenerative conditions including cardiovascular disease, diabetes, and liver and kidney disease. Biochemist Otto Warburg was awarded the Nobel Prize in 1931 for discovering that anaerobic cancer cells die in oxygen. This discovery makes ozone therapy an important modality in cancer treatment.
History of Medical Ozone
Despite its dubious status in the USA as an “alternative” treatment, for the past 150 years Ozone Therapy has been thoroughly studied and widely utilized throughout Europe and Asia. For US patients who encounter it for the first time it’s an interesting and curious treatment, because it seems so simple, natural and effective, that one wonders why so few US doctors use it. As a matter of fact, even though it is statistically one of the safest medical treatments known, until relatively recently, Ozone Therapy was illegal in many states, and patients had to travel to Mexico to find American doctors who practiced “Integrative Medicine” and whose specialization included Ozone Therapy.
Ozone Therapy has been effective for patients who are suffering from a wide variety of chronic microbial infections, fungal (yeast) such as Candida, Bacterial infections such as Spirochetes and Lyme Disease, MRSA infections and viruses such as Epstein Barr, Herpes (Simplex & Shingles), HIV and even Ebola, as well as a whole host of inflammatory diseases.
Here's a few of the many established beneficial effects of Ozone Therapy include: Dental caries (cavities), decreased blood cholesterol, increases red blood cell metabolism, increases oxygenation of tissues, increases mitochondrial production of ATP, preserves tissues suffering from hypoxic and ischemic conditions, and accelerates wound healing. Ozone Therapy comes with a long list of benefits as a complimentary medical approach in the treatment of various diseases: Cancer Multiple Sclerosis Arthritis Heart Disease Lyme Disease Autoimmune Disease Additional Health Benefits Include Anti-Aging Boost of the immune system Increased energy production in your cells Reduces the oxidation of your body Reduces the level of acidity of your body Kills bacteria and viruses Stimulates white blood cell production Fights infections Ozone Therapy – Scientific Perspective From a scientific perspective ozone: Stimulates mitochondrial function and causes an increase in mitochondrial numbers within every cell in your body. This results in a remarkable stimulation of the regenerative capacity and activity in every organ, tissue and gland in your body. Increases the metabolism of your red blood cells (glycolytic ↑ATP) Increases blood flow (perfusion) throughout your entire body (↑nitric oxide) Increases oxygen delivery to all your tissues. (↑2,3,DPG) Boosts your immune system Increases production of Interferons… which are your body’s prime defense against viruses Directly attacks the viral capsid … “shell” of all viruses… killing them Causes an increase in the generation and release of growth factors (from platelets), which helps healing and regeneration of damaged tissues. Ozone increases your body’s production of natural anti-oxidant molecules that protect you from oxidative stress and damage. (Up-regulation / Gene Modulation) Ozone Therapy – Clinical Perspective From the clinical perspective ozone: Kills pathogenic bacteria and viruses, including Lyme (and co-infections) Candida Viral infections like Herpes, HIV, Epstein-Bar and Hepatitis fungal infections. Boosts the immune system Stimulates a Powerful antioxidant response Effective treatment of chronic sinus infections Stimulates healing as well as regenerates damaged joints Helps heal brain trauma including seizures Effective on many skin conditions, including hard to heal wounds, ulcers and even MRSA Effective on soft tissue injuries and trigger points Effective on improving vision and curing ocular (eye) diseases such as Macular Degeneration, Diabetes related blindness etc. Decreases cholesterol Since ozone therapy is so powerful in helping to heal infected wounds, or wounds in general, cutting edge dental practices and periodontists rely on it during procedures and surgeries, where this is becoming more popular. How Ozone Therapy Works Ozone has different actions depending on its concentration and how it’s administered. While ozone does have a direct killing effect on bacteria, funguses, protozoa and viruses, its main mechanisms of action are by stimulating (modulating) our natural physiological immune and regenerative systems. Thus, ozone easily fits into the category of “biological therapy”, or “physiological therapy”. Ozone has six primary modes of therapeutic significance: 1. Regenerative Ozone injection into the shoulder Ozone injection into the shoulder By stimulating mitochondria, ozone supports and accelerates the body’s natural ability to heal damaged tissue and regenerate healthy tissue. Examples include ozone injections to heal damaged joints. It accomplishes this by stimulating the mitochondria of cells that are actively involved in regeneration, such as stem cells or the cells that generate new collagen in a damaged joint, or those that form new bones in the case of bone damage. Note: Every cell in your body is dependent on ATP from which it derives the energy it needs to perform its functions. ATP is generated in mitochondria. Therefore, if your cells have more ATP, they function better. From cells that make collagen, to cells that make your hormones, or make natural antioxidants, or detox your blood… everything is dependent on the health of your mitochondria. Ozone is better at supporting the health of your mitochondria than any other known substance. Interestingly, prokaryote cells which include all bacteria do NOT have mitochondria, so they are not helped by ozone. 2. Infectious Disease Wherein ozone attacks pathogenic infections by bacteria, fungi, protozoa and viruses, and stimulates the body’s natural immune defenses. This form of physiological therapy is called Oxidative Therapy. Note: Ozone attacks the cellular membranes (walls) of microbes, so all bacteria fungi, yeast and viruses are susceptible. Note: Ozone is also a powerful stimulator of immune functions by increasing your generation of interferon, tumor necrosis factor and Interleuken-2. All of these are essential in a healthy immune response to microbial infection attacks. Note: Bacteria can not develop resistance to ozone. 3. Cancer Wherein ozone attacks malignant cells, and protects healthy cells. It can also be a powerful adjunctive therapy to chemotherapy. As in #2 above, this form of physiological therapy is Oxidative. 4. As a Detox Agent DSAP (disseminated superficial actinic porokeratosis) before and after treatment with with high dose ozone therapy DSAP (disseminated superficial actinic porokeratosis) before and after treatment with high dose ozone therapy Ozone stimulates the body’s natural ability to generate its own anti-oxidants. This is particularly important for the health of the two organs that generate more oxidative activity than all other organs, namely, your liver and brain. 5. Anti-Oxidative Response Ozone stimulates a powerful anti-oxidative response by our bodies and has proven effective in subduing the overproduction of inflammatory cells such as those associated with Asthma, Diabetes, as well as other painful inflammatory diseases like arthritis, Fibromyalgia and others. 6. Oxygenation Ozone stimulates oxygen metabolism by empowering your red blood cells with greater cellular energy derived from glycolysis. This also increases the ability of your red blood cells to deliver greater quantity of oxygen to your tissues. This not only increases your body’s ability to regenerate new tissues, it directly attacks bacteria, who are anaerobic and are negatively affected in an oxygen rich environment. For more information see: Ozone therapy: A clinical review from The National Center for Biotechnology Information How Ozone is Administered As the clinical evidence for the effectiveness of Ozone therapy is gaining recognition, there are now several clinics throughout the country that are having remarkable results treating chronic complex infections, like Lyme and various viral infections with ozone. Intravenous (IV) The preferred method of administering ozone therapy is intensive intravenous (IV) ozone protocols. The most effective of these therapies is Hyperbaric ozone therapy with the Hermann device, also known as “Ten Pass” therapy. Watch the video : Why IV Ozone Therapy “The 10 Pass Device” is the Most Effective Most clinics combine ozone IV therapy with high potency vitamin IV therapy, for a synergistically fabulous impact on your overall health and wellbeing. Injection Ozone can be injected directly into joints and soft tissues. Topical Though Ozone is powerfully effective when administered as an IV, It has a similar effect when applied internally or topically in the form of ozonated oils such as olive oil. (Nikola Tesla was the first to develop these medicinal oils for physicians). Water can also be ozonated for drinking and bathing in. Limb Bagging Nasal insufflation of ozone for sinus problems Nasal insufflation of ozone for sinus problems Ozone gas, at precise concentrations, can be infused into a bag that is encapsulating a limb, (“limb bagging”), or used in ozone saunas. Insufflation Ozone can be infused directly into body cavities, called “insufflation”. (Rectal/colon, vaginal, ears, sinuses, bladder.) The Results In each of these cases, the ozone treats localized infections, and supports an accelerated healing of the inflamed tissue. Bottom line, ozone therapy is safe, natural and works physiologically to eradicate all sorts of infections and boost your overall health and wellbeing.
Learn More About the Science of Ozone
Therapy References Sagai M and Boccicorresponding V. Mechanisms of Action Involved in Ozone Therapy: Is Healing Induced via a Mild Oxidative Stress? 2011 Dec;20:10.1186/2045-9912-1-29. Elvis A and Ekta J. Ozone Therapy: A Clinical Review. 2011 Jan-Jun;2(1):66–70. Bocci V, Zanardi I and Travagli V. Ozone Acting on Human Blood Yields a Hormetic Dose-response Relationship. 2011 May;17;9:66. Simonetti L, Raffi L, Cenni P, Agati R and Leonardi M. Pharmacological Mechanisms Underlying Oxygen-Ozone Therapy for Herniated Disc. 2003 Sep;201-204. Lerner R and Eschenmoser A. Ozone in Biology. 2003 Mar;18;(6)3013-3015. Zargaran M, Fatahinia M and Mahmoudabadi A. The Efficacy of Gaseous Ozone Against Different Forms of Candida Albicans. 2017 Jun;3(2):26–32. Song M, Zeng Q, Xiang Y, Gao L, Huang J, Wu K and Lu J. The Antibacterial Effect of Topical Ozone on the Treatment of MRSA Skin Infection. 2018 Feb;17(2):2449–2455. Costanzo, M et al. Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription. European journal of histochemistry : EJH vol. 59,2 2515. 21 Apr. 2015. Baysan A, Lynch E. Effect of Ozone on the Oral Microbiota and Clinical Severity of Primary Root Caries. 2004 Feb;17(1):56-60. Ezeldin M, Leonardi M, Princiotta C, Dall’olio M, Tharwat M, Zaki M, Abdel-Wanis M and Cirillo L. Percutaneous Ozone Nucleolysis for Lumbar Disc Herniation. 2018 Sep;60(11):1231–1241. Borrelli E and Bocci V. Visual Improvement Following Ozone Therapy in Dry Age Related Macular Degeneration; a Review. 2013 Summer;2(2):47–51. Clavo B, Santana-Rodríguez N, Llontop P, Gutiérrez D, Suárez G, López L, Rovira G, Martínez-Sánchez G, González E, Jorge I, Perera C, Blanco J and Rodríguez-Esparragón F. Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted? 2018 Sep;7931849 Steppan J, Meaders T, Muto M and Murphy KJ. A Metaanalysis of the Effectiveness and Safety of Ozone Treatments for Herniated Lumbar Discs. 2010 Apr;21(4):534-48. Steppan J, Boxley C, Murphy K, Muto M, Balagurunathan K and Meaders T. Abstract No. 38: Ozone’s Mechanisms of Action for Relieving Pain Associated with Herniated Intervertebral Discs. 2009 Feb;V20:S16–S17 Scassellati C, Galoforo AC, Bonvicini C, Esposito C, Ricevuti G. Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Res Rev. 2020 Nov;63:101138. Molinari F, Simonetti V, Franzini M, Pandolfi S, Vaiano F, Valdenassi L, Liboni W. Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patients. Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(3):379-89. Gazioğlu Türkyılmaz G, Rumeli Ş, Bakır M. Effects of Major Ozone Autohemotherapy on Physical Functionality and Quality of Life in Fibromyalgia Syndrome: A Prospective Cross-sectional Study. Altern Ther Health Med. 2021 Sep;27(5):8-12. Tirelli U, Franzini M, Valdenassi L, Pisconti S, Taibi R, Torrisi C, Pandolfi S, Chirumbolo S. Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy – preliminary results on 100 patients. Eur Rev Med Pharmacol Sci. 2021 Sep;25(18):5871-5875. Regenerative Medicine Biological Allograft / Stem Cell (FDA:HCT/P) EBOO/F
